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KMID : 0378019760190010036
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New Medical Journal
1976 Volume.19 No. 1 p.36 ~ p.42
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Histochemical Studies on Changes of Renal Alkaline Phosphatase Activity during Recovery Periods after Acute CO-poisoned Mice
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Abstract
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The present investigation was to find out the changes of renal alkaline phosphatase (ALP) activity during recovery periods after carbon monoxide (CO) poisoning. For this purpose, the mice, were poisoned with 1 % CO for 1 hour and 0.5% CO for 8 hours. After acute CO-poisoning the experimental animal was exposed to fresh air for 1 to 24 hours. The changes of alkaline phosphatase activity was examined histochemically after exposure to fresh air by modified Gomori method. The following results were obtained; 1. Renal ALP activity was recovered after 18 hours exposure to fresh air in the case of 1% COpoisoning. 2. Renal ALP activity was recoverd after 24 hours exposure to fresh air in the case of 0.5% COpoisoning. 3. Renal ALP activity is changed remarkedly to brush border of proximal convoluted tubules.
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